Experience-dependent control of synaptic remodeling and structural plasticity by glia

Vita, Dominic J, Ferro, Austin, Cheadle, Lucas (June 2025) Experience-dependent control of synaptic remodeling and structural plasticity by glia. Current Opinion in Neurobiology, 93. p. 103059. ISSN 0959-4388

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URL: https://www.ncbi.nlm.nih.gov/pubmed/40479809

DOI: 10.1016/j.conb.2025.103059

Abstract

The central nervous system (CNS) integrates intrinsic molecular cues with sensory experience to shape synaptic connectivity between neurons. Once established, these emergent neural circuits remain plastic into adulthood to facilitate behavioral adaptations to changes in the sensory landscape. While sensory experience has been recognized as a major contributor to synaptic wiring since the foundational work of Hubel and Wiesel in the mid-1900s, the field has only recently begun to uncover the roles of nonneuronal cells, or glia, in experience-dependent aspects of synaptic refinement and remodeling. Herein, we review recent work demonstrating that many glial cell types-including invertebrate glia, astrocytes, microglia, and oligodendrocyte-lineage cells-participate in the experience-dependent remodeling of neural circuits across the lifespan.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > glia cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > glia cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > glia cells organs, tissues, organelles, cell types and functions
CSHL Authors:	Ferro, Austin Cheadle, Lucas Vita, Dominic
Communities:	CSHL labs > Cheadle lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	5 June 2025
Date Deposited:	09 Jun 2025 12:19
Last Modified:	09 Jun 2025 12:19
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41884

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