Maia-Silva, Diogo, Vakoc, C. R. (July 2024) A ΔNp63–MED12 axis drives basal-like identity in pancreatic cancer. Nature Genetics, 56 (7). pp. 1331-1332. ISSN 1061-4036
Abstract
Comprehensive dissection of the transcriptional basis of basal-like differentiation of pancreatic ductal adenocarcinoma (PDAC) revealed MED12 as a core regulator of this abnormal identity. Mechanistic studies demonstrate that MED12 cooperates with the basal-like master regulator transcription factor ΔNp63 by bridging it with the critical Mediator co-activator complex.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders diseases & disorders > cancer > cancer types > pancreatic cancer diseases & disorders > cancer > cancer types |
| CSHL Authors: | |
| Communities: | CSHL labs > Vakoc lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | July 2024 |
| Date Deposited: | 18 Mar 2025 12:21 |
| Last Modified: | 18 Mar 2025 12:21 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41824 |
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