Orderly specification and precise laminar deployment of mouse cortical projection neuron types through intermediate progenitors

Huilgol, Dhananjay, Levine, Jesse M, Galbavy, William, Wang, Bor-Shuen, Huang, Z Josh (March 2025) Orderly specification and precise laminar deployment of mouse cortical projection neuron types through intermediate progenitors. Developmental Cell. S1534-5807(25)00114. ISSN 1534-5807

URL: https://www.ncbi.nlm.nih.gov/pubmed/40068685

DOI: 10.1016/j.devcel.2025.02.009

Abstract

The cerebral cortex comprises diverse types of glutamatergic projection neurons (PNs) generated from radial glial progenitors (RGs) through either direct neurogenesis (dNG) or indirect neurogenesis (iNG) via intermediate progenitors (IPs). A foundational concept in corticogenesis is the "inside-out" model, whereby successive generations of PNs sequentially migrate first to deep and then progressively to more superficial layers. However, its biological significance remains unclear, and the role of iNG in this process is unknown. Using genetic strategies linking PN birth dating to projection mapping in mice, we found that the laminar deployment of IP-derived PNs substantially deviates from a stringent inside-out rule: PNs destined to non-consecutive layers are generated at the same time, and different PN types of the same layer are generated at non-contiguous times. The overarching scheme of iNG is the sequential specification and precise laminar deployment of projection-defined PN types, which may contribute to the orderly assembly of cortical output channels and processing streams.

Item Type:	Paper
Subjects:	organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent
CSHL Authors:	Huilgol, Dhananjay Levine, Jesse Galbavy, William Wang, Bor-Shuen Huang, Z. Josh
Communities:	CSHL labs > Huang lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	7 March 2025
Date Deposited:	14 Mar 2025 18:15
Last Modified:	14 Mar 2025 18:15
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41814

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