Langdon, Christopher, Engel, Tatiana A (February 2025) Latent circuit inference from heterogeneous neural responses during cognitive tasks. Nature Neuroscience. ISSN 1097-6256 (Public Dataset)
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Abstract
Higher cortical areas carry a wide range of sensory, cognitive and motor signals mixed in heterogeneous responses of single neurons tuned to multiple task variables. Dimensionality reduction methods that rely on correlations between neural activity and task variables leave unknown how heterogeneous responses arise from connectivity to drive behavior. We develop the latent circuit model, a dimensionality reduction approach in which task variables interact via low-dimensional recurrent connectivity to produce behavioral output. We apply the latent circuit inference to recurrent neural networks trained to perform a context-dependent decision-making task and find a suppression mechanism in which contextual representations inhibit irrelevant sensory responses. We validate this mechanism by confirming the behavioral effects of patterned connectivity perturbations predicted by the latent circuit model. We find similar suppression of irrelevant sensory responses in the prefrontal cortex of monkeys performing the same task. We show that incorporating causal interactions among task variables is critical for identifying behaviorally relevant computations from neural response data.
| Item Type: | Paper |
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| Subjects: | neurobiology neurobiology > neuroscience |
| CSHL Authors: | |
| Communities: | CSHL labs > Engel lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 10 February 2025 |
| Date Deposited: | 18 Feb 2025 13:40 |
| Last Modified: | 18 Feb 2025 13:40 |
| Related URLs: | |
| Dataset ID: |
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| URI: | https://repository.cshl.edu/id/eprint/41794 |
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