Sannigrahi, Achinta, De, Nayan, Bhunia, Debmalya, Bhadra, Jhuma (January 2025) Peptide nucleic acids: Recent advancements and future opportunities in biomedical applications. Bioorganic Chemistry, 155. p. 108146. ISSN 0045-2068
Abstract
Peptide nucleic acids (PNA), synthetic molecules comprising a peptide-like backbone and natural and unnatural nucleobases, have garnered significant attention for their potential applications in gene editing and other biomedical fields. The unique properties of PNA, particularly enhanced stability/specificity/affinity towards targeted DNA and RNA sequences, achieved significant attention recently for gene silencing, gene correction, antisense therapy, drug delivery, biosensing and other various diagnostic aspects. This review explores the structure, properties, and potential of PNA in transforming genetic engineering including potent biomedical challenges. In Addition, we explore future perspectives and potential limitations of PNA-based technologies, highlighting the need for further research and development to fully realize their therapeutic and biotechnological potential.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics bioinformatics > genomics and proteomics |
| CSHL Authors: | |
| Communities: | CSHL labs > Wigler lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 10 January 2025 |
| Date Deposited: | 21 Jan 2025 14:04 |
| Last Modified: | 21 Jan 2025 14:04 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41775 |
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