Why do patients with cancer die?

Boire, Adrienne, Burke, Katy, Cox, Thomas R, Guise, Theresa, Jamal-Hanjani, Mariam, Janowitz, Tobias, Kaplan, Rosandra, Lee, Rebecca, Swanton, Charles, Vander Heiden, Matthew G, Sahai, Erik (June 2024) Why do patients with cancer die? Nature Reviews Cancer. ISSN 1474-175X

PDF 10.1038.s41568-024-00708-4.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB)

Abstract

Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before death remain poorly understood. This scarcity of information, particularly the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of, and potentially extend, life for patients with late-stage cancer. In addition, earlier deployment of existing strategies to prolong quality of life is highly desirable. In this Roadmap, we review the proximal causes of mortality in patients with cancer and discuss current knowledge about the interconnections between mechanisms that contribute to mortality, before finally proposing new and improved avenues for data collection, research and the development of treatment strategies that may improve quality of life for patients.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders
CSHL Authors:	Janowitz, Tobias
Communities:	CSHL Cancer Center Program > Cancer Genetics and Genomics Program CSHL labs > Janowitz lab CSHL Cancer Center Program
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	19 June 2024
Date Deposited:	24 Jun 2024 12:47
Last Modified:	24 Jun 2024 12:47
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41585

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