Guo, Guangran, Amor, Corina (June 2024) SGLT2 regulates immune-mediated senolysis. Nature Aging. ISSN 2662-8465
Abstract
Inhibitors of sodium glucose co-transporter 2 (SGLT2) have long been used in the treatment of diabetes and cardiovascular disease, owing to their modulation of glucose levels. Katsuumi and colleagues now show that, in addition to their glycemic effects, SGLT2 inhibitors modulate senescence immune surveillance by downregulating PD-L1 expression on senescent cells.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence |
| CSHL Authors: | |
| Communities: | CSHL Cancer Center Program CSHL Cancer Center Program > Cellular Communication in Cancer Program CSHL labs > Amor lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 10 June 2024 |
| Date Deposited: | 12 Jun 2024 14:59 |
| Last Modified: | 12 Jun 2024 14:59 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41579 |
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