Bridging neuronal correlations and dimensionality reduction

Umakantha, Akash, Morina, Rudina, Cowley, Benjamin R, Snyder, Adam C, Smith, Matthew A, Yu, Byron M (September 2021) Bridging neuronal correlations and dimensionality reduction. Neuron, 109 (17). 2740-2754.e12. ISSN 0896-6273

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Abstract

Two commonly used approaches to study interactions among neurons are spike count correlation, which describes pairs of neurons, and dimensionality reduction, applied to a population of neurons. Although both approaches have been used to study trial-to-trial neuronal variability correlated among neurons, they are often used in isolation and have not been directly related. We first established concrete mathematical and empirical relationships between pairwise correlation and metrics of population-wide covariability based on dimensionality reduction. Applying these insights to macaque V4 population recordings, we found that the previously reported decrease in mean pairwise correlation associated with attention stemmed from three distinct changes in population-wide covariability. Overall, our work builds the intuition and formalism to bridge between pairwise correlation and population-wide covariability and presents a cautionary tale about the inferences one can make about population activity by using a single statistic, whether it be mean pairwise correlation or dimensionality.

Item Type:	Paper
Subjects:	organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal > mammal organism description > animal > mammal > primates > monkey organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organism description > animal > mammal > primates organs, tissues, organelles, cell types and functions > tissues types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:	Cowley, Benjamin
Communities:	CSHL labs > Cowley lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	1 September 2021
Date Deposited:	22 May 2024 19:54
Last Modified:	22 May 2024 19:54
PMCID:	PMC8505167
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41558

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