Grange, Pascal, Mitra, Partha P (April 2011) Algorithmic choice of coordinates for injections into the brain: encoding a neuroanatomical atlas on a grid. (Submitted)
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Abstract
Given an atlas of the brain and a number of injections to be performed in order to map out the connections between parts of the brain, we propose an algorithm to compute the coordinates of the injections. The algorithm is designed to sample the brain in the most homogeneous way compatible with the separation of brain regions. It can be applied to other species for which a neuroanatomical atlas is available. The computation is tested on the annotation at a resolution of 25 microns corresponding to the Allen Reference Atlas, which is hierarchical and consists of 209 regions. The resulting injection coordinates are being used for the injection protocol of the Mouse Brain Architecture project. Due to its large size and layered structure, the cerebral cortex is treated in a separate algorithm, which is more adapted to its geometry.
| Item Type: | Paper |
|---|---|
| Subjects: | Investigative techniques and equipment > brain atlas organism description > animal > mammal > rodent > mouse neurobiology > neuroanatomy |
| CSHL Authors: | |
| Communities: | CSHL labs > Mitra lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 13 April 2011 |
| Date Deposited: | 13 Oct 2023 15:51 |
| Last Modified: | 13 Oct 2023 15:51 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41248 |
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