Network cloning using DNA barcodes

Shuvaev, Sergey A, Başerdem, Batuhan, Zador, Anthony, Koulakov, Alexei A (November 2016) Network cloning using DNA barcodes. arXiv. (Submitted)

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Abstract

The ability to measure or manipulate network connectivity is the main challenge in the field of connectomics. Recently, a set of approaches has been developed that takes advantage of next generation DNA sequencing to scan connections between neurons into a set of DNA barcodes. Individual DNA sequences called markers represent single neurons, while pairs of markers, called barcodes contain information about connections. Here we propose a strategy for 'copying' or 'cloning' connectivity contained in barcodes into a clean slate tabula rasa network. We show that a one marker one cell (OMOC) rule, which forces all markers with the same sequence to condense into the same neuron, leads to fast and reliable formation of desired connectivity in a new network. We show that OMOC rule yields convergence in a number of steps given by a power law function of the network size. We thus propose that copying network connectivity from one network to another is theoretically possible.

Item Type:	Paper
Subjects:	Investigative techniques and equipment > probes > DNA probes organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks
CSHL Authors:	Shuvaev, Sergey Zador, Anthony M. Koulakov, Alexei A. Baserdem, Batuhan
Communities:	CSHL labs > Koulakov lab CSHL labs > Zador lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	2 November 2016
Date Deposited:	13 Oct 2023 14:08
Last Modified:	02 Jan 2024 19:53
Related URLs:	Author
URI:	https://repository.cshl.edu/id/eprint/41225

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