Escalating de-escalation in breast cancer treatment

Sacchini, Virgilio, Norton, Larry (September 2022) Escalating de-escalation in breast cancer treatment. Breast Cancer Research and Treatment, 195 (2). pp. 85-90. ISSN 0167-6806

DOI: 10.1007/s10549-022-06685-2


Efforts have continually been made to de-escalate treatment for breast cancer, with the goal of balancing oncologic outcomes with complications and patient quality of life. In the early 2000s, two landmark studies firmly established that conservative treatment approaches for breast cancer can be safe and effective. More recently, neoadjuvant chemotherapy has gained momentum as a potential standard of care for breast cancer. An important question has thus arisen: Can neoadjuvant approaches themselves be de-escalated to further minimize adverse treatment effects while maintaining oncological outcomes? In this editorial, we look at the available evidence and assess current trends in treatment de-escalation for women with breast cancer.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
Investigative techniques and equipment
diseases & disorders > neoplasms
Investigative techniques and equipment > radiation treatment and equipment
diseases & disorders > cancer > cancer types > breast cancer
diseases & disorders > cancer > cancer types
CSHL Authors:
Communities: CSHL labs > Wigler lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: September 2022
Date Deposited: 03 Oct 2023 19:44
Last Modified: 17 Jan 2024 14:55
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