Rho GTPases

Lukey, MJ, Qiu, Y, Yang, WH, Cerione, RA (January 2022) Rho GTPases. In: Encyclopedia of Cell Biology: Volume 1-6, Second Edition. UNSPECIFIED, pp. 260-271. ISBN 9780128216248

Abstract

The Ras-homology (Rho) GTPases were initially linked to regulation of the actin cytoskeleton, with downstream impacts on cellular morphology, polarity, adhesion, and migration. Subsequent studies have revealed that the Rho GTPases are involved in highly diverse cellular and biological functions during development, health, and disease. These include endocytosis and exocytosis, vesicle trafficking, transcriptional regulation, and cell cycle progression. Here, we present an overview of the ‘traditional’ cellular functions of Rho GTPases in regulating the actin cytoskeleton, providing a history of key discoveries in the Rho GTPase field since the identification of RhoA more than three decades ago. We then summarize the physiological roles of Rho GTPases during developmental processes including formation of the central nervous system, and we discuss how aberrant Rho GTPase signaling contributes to pathological conditions including cancer.

Item Type:	Book Section
Subjects:	bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Rho bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > actin bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:	Lukey, Michael Qiu, Yijian Yang, Wen-Hsuan
Communities:	CSHL labs > Lukey lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	1 January 2022
Date Deposited:	28 Sep 2023 17:39
Last Modified:	16 Jan 2024 18:46
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41031

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