Lukey, MJ, Qiu, Y, Yang, WH, Cerione, RA
(January 2022)
Rho GTPases.
In:
Encyclopedia of Cell Biology: Volume 1-6, Second Edition.
UNSPECIFIED, pp. 260-271.
ISBN 9780128216248
Abstract
The Ras-homology (Rho) GTPases were initially linked to regulation of the actin cytoskeleton, with downstream impacts on cellular morphology, polarity, adhesion, and migration. Subsequent studies have revealed that the Rho GTPases are involved in highly diverse cellular and biological functions during development, health, and disease. These include endocytosis and exocytosis, vesicle trafficking, transcriptional regulation, and cell cycle progression. Here, we present an overview of the ‘traditional’ cellular functions of Rho GTPases in regulating the actin cytoskeleton, providing a history of key discoveries in the Rho GTPase field since the identification of RhoA more than three decades ago. We then summarize the physiological roles of Rho GTPases during developmental processes including formation of the central nervous system, and we discuss how aberrant Rho GTPase signaling contributes to pathological conditions including cancer.
| Item Type: |
Book Section
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| Subjects: |
bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Rho
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > actin
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types |
| CSHL Authors: |
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| Communities: |
CSHL labs > Lukey lab |
| SWORD Depositor: |
CSHL Elements
|
| Depositing User: |
CSHL Elements
|
| Date: |
1 January 2022 |
| Date Deposited: |
28 Sep 2023 17:39 |
| Last Modified: |
16 Jan 2024 18:46 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/41031 |
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