The dynamics and geometry of choice in premotor cortex

Genkin, Mikhail, Shenoy, Krishna V, Chandrasekaran, Chandramouli, Engel, Tatiana A (July 2023) The dynamics and geometry of choice in premotor cortex. (Submitted)

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Abstract

The brain represents sensory variables in the coordinated activity of neural populations, in which tuning curves of single neurons define the geometry of the population code. Whether the same coding principle holds for dynamic cognitive variables remains unknown because internal cognitive processes unfold with a unique time course on single trials observed only in the irregular spiking of heterogeneous neural populations. Here we show the existence of such a population code for the dynamics of choice formation in the primate premotor cortex. We developed an approach to simultaneously infer population dynamics and tuning functions of single neurons to the population state. Applied to spike data recorded during decision-making, our model revealed that populations of neurons encoded the same dynamic variable predicting choices, and heterogeneous firing rates resulted from the diverse tuning of single neurons to this decision variable. The inferred dynamics indicated an attractor mechanism for decision computation. Our results reveal a common geometric principle for neural encoding of sensory and dynamic cognitive variables.

Item Type:	Paper
Subjects:	organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal > mammal organs, tissues, organelles, cell types and functions > tissues types and functions > motor cortex organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organism description > animal > mammal > primates organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Genkin, Mikhail Engel, Tatiana
Communities:	CSHL labs > Engel lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	25 July 2023
Date Deposited:	21 Sep 2023 17:34
Last Modified:	08 Jan 2024 20:37
PMCID:	PMC10401920
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/40945

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