NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

Adrover, Jose M, McDowell, Sheri AC, He, Xue-Yan, Quail, Daniela F, Egeblad, Mikala (February 2023) NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps. Cancer Cell. ISSN 1535-6108

URL: https://www.ncbi.nlm.nih.gov/pubmed/36827980
DOI: 10.1016/j.ccell.2023.02.001

Abstract

Neutrophils are major effectors and regulators of the immune system. They play critical roles not only in the eradication of pathogens but also in cancer initiation and progression. Conversely, the presence of cancer affects neutrophil activity, maturation, and lifespan. By promoting or repressing key neutrophil functions, cancer cells co-opt neutrophil biology to their advantage. This co-opting includes hijacking one of neutrophils' most striking pathogen defense mechanisms: the formation of neutrophil extracellular traps (NETs). NETs are web-like filamentous extracellular structures of DNA, histones, and cytotoxic granule-derived proteins. Here, we discuss the bidirectional interplay by which cancer stimulates NET formation, and NETs in turn support disease progression. We review how vascular dysfunction and thrombosis caused by neutrophils and NETs underlie an elevated risk of death from cardiovascular events in cancer patients. Finally, we propose therapeutic strategies that may be effective in targeting NETs in the clinical setting.

Item Type: Paper
Subjects: bioinformatics
diseases & disorders > cancer
diseases & disorders > cardiovascular diseases
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > histone
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > immunity
organs, tissues, organelles, cell types and functions > organs types and functions > metabolism
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils
organs, tissues, organelles, cell types and functions > organs types and functions
organs, tissues, organelles, cell types and functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Egeblad lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 18 February 2023
Date Deposited: 28 Feb 2023 17:17
Last Modified: 08 Jan 2024 15:54
PMCID: PMC10280682
URI: https://repository.cshl.edu/id/eprint/40845

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