Long-range functional loops in the mouse olfactory system and their roles in computing odor identity

Chae, Honggoo, Banerjee, Arkarup, Dussauze, Marie, Albeanu, Dinu F (September 2022) Long-range functional loops in the mouse olfactory system and their roles in computing odor identity. Neuron. S0896-6273(22)00810. ISSN 0896-6273

URL: https://www.ncbi.nlm.nih.gov/pubmed/36174573
DOI: 10.1016/j.neuron.2022.09.005


Elucidating the neural circuits supporting odor identification remains an open challenge. Here, we analyze the contribution of the two output cell types of the mouse olfactory bulb (mitral and tufted cells) to decode odor identity and concentration and its dependence on top-down feedback from their respective major cortical targets: piriform cortex versus anterior olfactory nucleus. We find that tufted cells substantially outperform mitral cells in decoding both odor identity and intensity. Cortical feedback selectively regulates the activity of its dominant bulb projection cell type and implements different computations. Piriform feedback specifically restructures mitral responses, whereas feedback from the anterior olfactory nucleus preferentially controls the gain of tufted representations without altering their odor tuning. Our results identify distinct functional loops involving the mitral and tufted cells and their cortical targets. We suggest that in addition to the canonical mitral-to-piriform pathway, tufted cells and their target regions are ideally positioned to compute odor identity.

Item Type: Paper
Subjects: organism description > animal
organism description > animal behavior
organism description > animal > mammal
organism description > animal > mammal > rodent > mouse
organism description > animal behavior > odor recognition
organism description > animal behavior > olfactory
organism description > animal > mammal > rodent
CSHL Authors:
Communities: CSHL labs > Albeanu lab
CSHL labs > Banerjee lab
School of Biological Sciences > Publications
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 26 September 2022
Date Deposited: 06 Oct 2022 23:27
Last Modified: 29 Feb 2024 16:58
PMCID: PMC9742324
URI: https://repository.cshl.edu/id/eprint/40728

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