Chae, Honggoo, Banerjee, Arkarup, Dussauze, Marie, Albeanu, Dinu F (September 2022) Long-range functional loops in the mouse olfactory system and their roles in computing odor identity. Neuron. S0896-6273(22)00810. ISSN 0896-6273
Abstract
Elucidating the neural circuits supporting odor identification remains an open challenge. Here, we analyze the contribution of the two output cell types of the mouse olfactory bulb (mitral and tufted cells) to decode odor identity and concentration and its dependence on top-down feedback from their respective major cortical targets: piriform cortex versus anterior olfactory nucleus. We find that tufted cells substantially outperform mitral cells in decoding both odor identity and intensity. Cortical feedback selectively regulates the activity of its dominant bulb projection cell type and implements different computations. Piriform feedback specifically restructures mitral responses, whereas feedback from the anterior olfactory nucleus preferentially controls the gain of tufted representations without altering their odor tuning. Our results identify distinct functional loops involving the mitral and tufted cells and their cortical targets. We suggest that in addition to the canonical mitral-to-piriform pathway, tufted cells and their target regions are ideally positioned to compute odor identity.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal organism description > animal behavior organism description > animal > mammal organism description > animal > mammal > rodent > mouse organism description > animal behavior > odor recognition organism description > animal behavior > olfactory organism description > animal > mammal > rodent |
| CSHL Authors: | |
| Communities: | CSHL labs > Albeanu lab CSHL labs > Banerjee lab School of Biological Sciences > Publications |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 26 September 2022 |
| Date Deposited: | 06 Oct 2022 23:27 |
| Last Modified: | 29 Feb 2024 16:58 |
| PMCID: | PMC9742324 |
| URI: | https://repository.cshl.edu/id/eprint/40728 |
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