Neutrophil phenotypes and functions in cancer: A consensus statement.

Quail, Daniela F, Amulic, Borko, Aziz, Monowar, Barnes, Betsy J, Eruslanov, Evgeniy, Fridlender, Zvi G, Goodridge, Helen S, Granot, Zvi, Hidalgo, Andrés, Huttenlocher, Anna, Kaplan, Mariana J, Malanchi, Ilaria, Merghoub, Taha, Meylan, Etienne, Mittal, Vivek, Pittet, Mikael J, Rubio-Ponce, Andrea, Udalova, Irina A, van den Berg, Timo K, Wagner, Denisa D, Wang, Ping, Zychlinsky, Arturo, de Visser, Karin E, Egeblad, Mikala, Kubes, Paul (June 2022) Neutrophil phenotypes and functions in cancer: A consensus statement. Journal of Experimental Medicine, 219 (6). e20220011. ISSN 0022-1007

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Abstract

Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.

Item Type:	Paper
Subjects:	diseases & disorders diseases & disorders > neoplasms organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > immunity diseases & disorders > inflammation organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils organs, tissues, organelles, cell types and functions
CSHL Authors:	Egeblad, Mikala
Communities:	CSHL labs > Egeblad lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	6 June 2022
Date Deposited:	17 May 2022 14:13
Last Modified:	16 Jan 2024 21:26
PMCID:	PMC9086501
URI:	https://repository.cshl.edu/id/eprint/40607

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