Large-scale neural recordings call for new insights to link brain and behavior

Urai, Anne E, Doiron, Brent, Leifer, Andrew M, Churchland, Anne K (January 2022) Large-scale neural recordings call for new insights to link brain and behavior. Nature Neuroscience. ISSN 1097-6256

Abstract

Neuroscientists today can measure activity from more neurons than ever before, and are facing the challenge of connecting these brain-wide neural recordings to computation and behavior. In the present review, we first describe emerging tools and technologies being used to probe large-scale brain activity and new approaches to characterize behavior in the context of such measurements. We next highlight insights obtained from large-scale neural recordings in diverse model systems, and argue that some of these pose a challenge to traditional theoretical frameworks. Finally, we elaborate on existing modeling frameworks to interpret these data, and argue that the interpretation of brain-wide neural recordings calls for new theoretical approaches that may depend on the desired level of understanding. These advances in both neural recordings and theory development will pave the way for critical advances in our understanding of the brain.

Item Type:	Paper
Subjects:	Investigative techniques and equipment organism description > animal behavior organs, tissues, organelles, cell types and functions > organs types and functions > brain Investigative techniques and equipment > brain atlas organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions Publication Type > review
CSHL Authors:	Urai, Anne Churchland, Anne K.
Communities:	CSHL labs > Churchland lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	3 January 2022
Date Deposited:	05 Jan 2022 16:45
Last Modified:	17 Jan 2024 15:51
URI:	https://repository.cshl.edu/id/eprint/40472

Actions (login required)

Administrator's edit/view item