Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits

Golding, Bruno, Pouchelon, Gabrielle, Bellone, Camilla, Murthy, Sahana, Di Nardo, Ariel A, Govindan, Subashika, Ogawa, Masahuro, Shimogori, Tomomi, Lüscher, Christian, Dayer, Alexandre, Jabaudon, Denis (March 2014) Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits. Neuron, 81 (5). pp. 1057-1069. ISSN 0896-6273

URL: https://www.ncbi.nlm.nih.gov/pubmed/24607228
DOI: 10.1016/j.neuron.2014.01.032

Abstract

Inhibitory interneurons (INs) critically control the excitability and plasticity of neuronal networks, but whether activity can direct INs into specific circuits during development is unknown. Here, we report that in the dorsal lateral geniculate nucleus (dLGN), which relays retinal input to the cortex, circuit activity is required for the migration, molecular differentiation, and functional integration of INs. We first characterize the prenatal origin and molecular identity of dLGN INs, revealing their recruitment from an Otx2(+) neuronal pool located in the adjacent ventral LGN. Using time-lapse and electrophysiological recordings, together with genetic and pharmacological perturbation of retinal waves, we show that retinal activity directs the navigation and circuit incorporation of dLGN INs during the first postnatal week, thereby regulating the inhibition of thalamocortical circuits. These findings identify an input-dependent mechanism regulating IN migration and circuit inhibition, which may account for the progressive recruitment of INs into expanding excitatory circuits during evolution.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons
organs, tissues, organelles, cell types and functions > tissues types and functions > retina
organs, tissues, organelles, cell types and functions > tissues types and functions > thalamus
organism description > animal behavior > visual
CSHL Authors:
Communities: CSHL labs > Pouchelon lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 5 March 2014
Date Deposited: 23 Dec 2021 14:21
Last Modified: 23 Dec 2021 14:21
URI: https://repository.cshl.edu/id/eprint/40467

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