Golding, Bruno, Pouchelon, Gabrielle, Bellone, Camilla, Murthy, Sahana, Di Nardo, Ariel A, Govindan, Subashika, Ogawa, Masahuro, Shimogori, Tomomi, Lüscher, Christian, Dayer, Alexandre, Jabaudon, Denis (March 2014) Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits. Neuron, 81 (5). pp. 1057-1069. ISSN 0896-6273
Abstract
Inhibitory interneurons (INs) critically control the excitability and plasticity of neuronal networks, but whether activity can direct INs into specific circuits during development is unknown. Here, we report that in the dorsal lateral geniculate nucleus (dLGN), which relays retinal input to the cortex, circuit activity is required for the migration, molecular differentiation, and functional integration of INs. We first characterize the prenatal origin and molecular identity of dLGN INs, revealing their recruitment from an Otx2(+) neuronal pool located in the adjacent ventral LGN. Using time-lapse and electrophysiological recordings, together with genetic and pharmacological perturbation of retinal waves, we show that retinal activity directs the navigation and circuit incorporation of dLGN INs during the first postnatal week, thereby regulating the inhibition of thalamocortical circuits. These findings identify an input-dependent mechanism regulating IN migration and circuit inhibition, which may account for the progressive recruitment of INs into expanding excitatory circuits during evolution.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons organs, tissues, organelles, cell types and functions > tissues types and functions > retina organs, tissues, organelles, cell types and functions > tissues types and functions > thalamus organism description > animal behavior > visual |
| CSHL Authors: | |
| Communities: | CSHL labs > Pouchelon lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 5 March 2014 |
| Date Deposited: | 23 Dec 2021 14:21 |
| Last Modified: | 23 Dec 2021 14:21 |
| URI: | https://repository.cshl.edu/id/eprint/40467 |
Actions (login required)
 |
Administrator's edit/view item |