Rats use memory confidence to guide decisions.

Joo, Hannah R, Liang, Hexin, Chung, Jason E, Geaghan-Breiner, Charlotte, Fan, Jiang Lan, Nachman, Benjamin P, Kepecs, Adam, Frank, Loren M (August 2021) Rats use memory confidence to guide decisions. Current Biology. ISSN 0960-9822

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URL: https://www.ncbi.nlm.nih.gov/pubmed/34473948
DOI: 10.1016/j.cub.2021.08.013


Memory enables access to past experiences to guide future behavior. Humans can determine which memories to trust (high confidence) and which to doubt (low confidence). How memory retrieval, memory confidence, and memory-guided decisions are related, however, is not understood. In particular, how confidence in memories is used in decision making is unknown. We developed a spatial memory task in which rats were incentivized to gamble their time: betting more following a correct choice yielded greater reward. Rat behavior reflected memory confidence, with higher temporal bets following correct choices. We applied machine learning to identify a memory decision variable and built a generative model of memories evolving over time that accurately predicted both choices and confidence reports. Our results reveal in rats an ability thought to exist exclusively in primates and introduce a unified model of memory dynamics, retrieval, choice, and confidence.

Item Type: Paper
Subjects: organism description > animal
organism description > animal behavior
bioinformatics > computational biology
organism description > animal behavior > decision making
organism description > animal > mammal
organism description > animal behavior > memory
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent
CSHL Authors:
Communities: CSHL labs > Kepecs lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 30 August 2021
Date Deposited: 07 Sep 2021 13:36
Last Modified: 24 Jan 2024 21:22
PMCID: PMC8551068
URI: https://repository.cshl.edu/id/eprint/40342

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