Cable, Jennifer, Greenbaum, Benjamin, Pe'er, Dana, Bollard, Catherine M, Bruni, Sofia, Griffin, Matthew E, Allison, James P, Wu, Catherine J, Subudhi, Sumit K, Mardis, Elaine R, Brentjens, Renier, Sosman, Jeffry A, Cemerski, Saso, Zavitsanou, Anastasia-Maria, Proia, Theresa, Egeblad, Mikala, Nolan, Garry, Goswami, Sangeeta, Spranger, Stefani, Mackall, Crystal L (November 2020) Frontiers in cancer immunotherapy-a symposium report. Annals of the New York Academy of Sciences. ISSN 0077-8923
Abstract
Cancer immunotherapy has dramatically changed the approach to cancer treatment. The aim of targeting the immune system to recognize and destroy cancer cells has afforded many patients the prospect of achieving deep, long-term remission and potential cures. However, many challenges remain for achieving the goal of effective immunotherapy for all cancer patients. Checkpoint inhibitors have been able to achieve long-term responses in a minority of patients, yet improving response rates with combination therapies increases the possibility of toxicity. Chimeric antigen receptor T cells have demonstrated high response rates in hematological cancers, although most patients experience relapse. In addition, some cancers are notoriously immunologically "cold" and typically are not effective targets for immunotherapy. Overcoming these obstacles will require new strategies to improve upon the efficacy of current agents, identify biomarkers to select appropriate therapies, and discover new modalities to expand the accessibility of immunotherapy to additional tumor types and patient populations.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders Investigative techniques and equipment diseases & disorders > neoplasms Investigative techniques and equipment > biomarker diseases & disorders > cancer > drugs and therapies diseases & disorders > cancer > drugs and therapies > Immunotherapy |
| CSHL Authors: | |
| Communities: | CSHL labs > Egeblad lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 13 November 2020 |
| Date Deposited: | 03 Feb 2021 16:47 |
| Last Modified: | 29 Jan 2024 20:34 |
| URI: | https://repository.cshl.edu/id/eprint/39840 |
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