Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Cousins, A. R., Ritson, D., Sharma, P., Stevens, M. F., Moses, J. E., Searle, M. S. (December 2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chem Commun (Camb), 50 (96). pp. 15202-5. ISSN 1359-7345

URL: https://pubmed.ncbi.nlm.nih.gov/25338751/

DOI: 10.1039/c4cc07487d

Abstract

Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based 'click' ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.

Item Type:	Paper
Additional Information:	Chemical communications (Cambridge, England)
CSHL Authors:	Moses, John E.
Depositing User:	Matthew Dunn
Date:	14 December 2014
Date Deposited:	08 Jan 2021 18:08
Last Modified:	08 Jan 2021 18:08
URI:	https://repository.cshl.edu/id/eprint/39560

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