Lombardo, C. M., MartÃnez, I. S., Haider, S., Gabelica, V., De Pauw, E., Moses, J. E., Neidle, S. (December 2010) Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Chem Commun (Camb), 46 (48). pp. 9116-8. ISSN 1359-7345
DOI: 10.1039/c0cc02917c
Abstract
A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Acridines Computer Simulation Drug Design *G-Quadruplexes Ligands Small Molecule Libraries Spectrometry, Mass, Electrospray Ionization Structure-Activity Relationship Telomere/*chemistry Triazoles/*chemistry |
| Communities: | CSHL labs > Moses lab |
| Highlight: | Moses, John E. |
| Depositing User: | Matthew Dunn |
| Date: | 28 December 2010 |
| Date Deposited: | 19 Apr 2021 20:22 |
| Last Modified: | 19 Apr 2021 20:22 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/39540 |
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