Kurtz, D. T. (1981) Hormonal Inducibility of Rat Alpha-2u Globulin Genes in Transfected Mouse Cells. Nature (London), 291 (5817). pp. 629-631.
DOI: 10.1038/291629a0
Abstract
Two different genes, coding for the hormonally regulated rat liver protein .alpha.2u globulin, were introduced into mouse Ltk- cells through cotransfection with the HSV-1 [herpes simplex virus type 1] thymidine kinase gene. Copies of the .alpha.2u globulin genes [3-10] were detected in several tk+ clones, over 50% of which could be induced with dexamethasone to produce .alpha.2u globulin mRNA and protein. The information necessary for hormonal response evidently is contained in the DNA fragment used for transfer.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription |
| CSHL Authors: | |
| Communities: | Cold Spring Harbor Laboratory of Quantitative Biology |
| Depositing User: | Elizabeth Pessala |
| Date: | 1981 |
| Date Deposited: | 26 May 2020 18:43 |
| Last Modified: | 26 May 2020 18:43 |
| URI: | https://repository.cshl.edu/id/eprint/39407 |
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