Targeting Potential Drivers of COVID-19: Neutrophil Extracellular Traps

Barnes, B.J., Adrover, J.M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J.M., DaBler-Plenker, J., Guerci, P., Huynh, C., Knight, J.S., Loda, M., Looney, M.R., McAllister, F., Rayes, R., Renaud, S., Rousseau, S., Salvatore, S., Schwartz, R.E., Spicer, J.D., Yost, C.C., Weber, A., Zuo, Y., Egeblad, M. (June 2020) Targeting Potential Drivers of COVID-19: Neutrophil Extracellular Traps. J Exp Med, 217 (6). e20200652. ISSN 1540-9538

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URL: https://pubmed.ncbi.nlm.nih.gov/32302401/

DOI: 10.1084/jem.20200652

Abstract

Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.

Item Type:	Paper
Subjects:	diseases & disorders diseases & disorders > viral diseases organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions diseases & disorders > viral diseases > coronavirus diseases & disorders > viral diseases > coronavirus > covid 19 organs, tissues, organelles, cell types and functions > organs types and functions > lung organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions
CSHL Authors:	Egeblad, Mikala DaBler-Plenker, Juliane Adrover, Jose M.
Communities:	CSHL Cancer Center Program > Cellular Communication in Cancer Program CSHL labs > Egeblad lab CSHL Cancer Center Program CSHL Cancer Center Shared Resources > Microscopy Service
Depositing User:	Adrian Gomez
Date:	1 June 2020
Date Deposited:	22 Apr 2020 17:52
Last Modified:	13 Feb 2024 19:50
PMCID:	PMC7161085
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/39246

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