Yan, X., Hu, Z., Feng, Y., Hu, X., Yuan, J., Zhao, S. D., Zhang, Y., Yang, L., Shan, W., He, Q., Fan, L., Kandalaft, L. E., Tanyi, J. L., Li, C., Yuan, C. X., Zhang, D., Yuan, H., Hua, K., Lu, Y., Katsaros, D., Huang, Q., Montone, K., Fan, Y., Coukos, G., Boyd, J., Sood, A. K., Rebbeck, T., Mills, G. B., Dang, C. V., Zhang, L. (2015) Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Cancer Cell, 28 (4). pp. 529-540. ISSN 1535-6108
Abstract
The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments. © 2015 Elsevier Inc.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > long non-coding RNA |
| CSHL Authors: | |
| Communities: | CSHL labs > Boyd lab |
| Highlight: | Boyd, Jeff |
| Depositing User: | Adrian Gomez |
| Date: | 2015 |
| Date Deposited: | 13 Mar 2020 18:54 |
| Last Modified: | 31 May 2020 18:50 |
| PMCID: | PMC4777353 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/39210 |
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