Gene Amplification Accompanies Low Level Increases in the Activity of Di Hydro Folate Reductase in Anti Folate Resistant Chinese Hamster Lung Cells Containing Abnormally Banding Chromosomes

Lewis, J. A., Biedler, J. L., Melera, P. W. (1982) Gene Amplification Accompanies Low Level Increases in the Activity of Di Hydro Folate Reductase in Anti Folate Resistant Chinese Hamster Lung Cells Containing Abnormally Banding Chromosomes. Journal of Cell Biology, 94 (2). pp. 418-424.

URL: https://pubmed.ncbi.nlm.nih.gov/7107708

DOI: 10.1083/jcb.94.2.418

Abstract

Three independently-derived, antifolate-resistant Chinese hamster lung cell lines that exhibit low level increases in dihydrofolate reductase (DHFR) activity, i.e., 3-5 fold vs. controls, were compared with drug-sensitive cells to determine relative DHFR gene content.

Item Type:	Paper
Subjects:	Investigative techniques and equipment > comparative genomic hybridization Investigative techniques and equipment > assays > comparative genomic hybridization
CSHL Authors:	Lewis, James
Communities:	Cold Spring Harbor Laboratory of Quantitative Biology
Depositing User:	Elizabeth Pessala
Date:	1982
Date Deposited:	31 Mar 2020 19:58
Last Modified:	31 Mar 2020 19:58
PMCID:	PMC2112886
URI:	https://repository.cshl.edu/id/eprint/39124

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