Open access resource for cellular-resolution analyses of corticocortical connectivity in the marmoset monkey

Majka, P., Bai, S., Bakola, S., Bednarek, S., Chan, J. M., Jermakow, N., Passarelli, L., Reser, D. H., Theodoni, P., Worthy, K. H., Wang, X. J., Wojcik, D. K., Mitra, P. P., Rosa, M. G. P. (February 2020) Open access resource for cellular-resolution analyses of corticocortical connectivity in the marmoset monkey. Nat Commun, 11 (1). p. 1133. ISSN 2041-1723 (Public Dataset)

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Abstract

Understanding the principles of neuronal connectivity requires tools for efficient quantification and visualization of large datasets. The primate cortex is particularly challenging due to its complex mosaic of areas, which in many cases lack clear boundaries. Here, we introduce a resource that allows exploration of results of 143 retrograde tracer injections in the marmoset neocortex. Data obtained in different animals are registered to a common stereotaxic space using an algorithm guided by expert delineation of histological borders, allowing accurate assignment of connections to areas despite interindividual variability. The resource incorporates tools for analyses relative to cytoarchitectural areas, including statistical properties such as the fraction of labeled neurons and the percentage of supragranular neurons. It also provides purely spatial (parcellation-free) data, based on the stereotaxic coordinates of 2 million labeled neurons. This resource helps bridge the gap between high-density cellular connectivity studies in rodents and imaging-based analyses of human brains.

Item Type:	Paper
Subjects:	organism description > animal organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex organism description > animal > mammal organism description > animal > mammal > primates > monkey > marmoset organism description > animal > mammal > primates > monkey organs, tissues, organelles, cell types and functions > tissues types and functions > neocortex organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions organism description > animal > mammal > primates organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Mitra, Partha P.
Communities:	CSHL labs > Mitra lab
Depositing User:	Adrian Gomez
Date:	28 February 2020
Date Deposited:	04 Mar 2020 14:33
Last Modified:	01 Feb 2024 16:06
PMCID:	PMC7048793
Related URLs:	Publisher
Dataset ID:	http://marmosetbrain.org https://github.com/Neuroinflab/marmosetbrain.org https://github.com/Neuroinflab/analysis.marmosetbrain.org
URI:	https://repository.cshl.edu/id/eprint/39071

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