Lukey, M. J., Wilson, K. F., Cerione, R. A. (September 2013) Therapeutic strategies impacting cancer cell glutamine metabolism. Future Med Chem, 5 (14). pp. 1685-700. ISSN 1756-8927
Abstract
The metabolic adaptations that support oncogenic growth can also render cancer cells dependent on certain nutrients. Along with the Warburg effect, increased utilization of glutamine is one of the metabolic hallmarks of the transformed state. Glutamine catabolism is positively regulated by multiple oncogenic signals, including those transmitted by the Rho family of GTPases and by c-Myc. The recent identification of mechanistically distinct inhibitors of glutaminase, which can selectively block cellular transformation, has revived interest in the possibility of targeting glutamine metabolism in cancer therapy. Here, we outline the regulation and roles of glutamine metabolism within cancer cells and discuss possible strategies for, and the consequences of, impacting these processes therapeutically.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Rho bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTP binding protein organs, tissues, organelles, cell types and functions > organs types and functions > metabolism |
| CSHL Authors: | |
| Communities: | CSHL labs > Lukey lab |
| Depositing User: | Adrian Gomez |
| Date: | September 2013 |
| Date Deposited: | 28 Jan 2020 16:13 |
| Last Modified: | 28 Jan 2020 16:13 |
| PMCID: | PMC4154374 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/38941 |
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