Targeting amino acid metabolism for cancer therapy

Lukey, M. J., Katt, W. P., Cerione, R. A. (May 2017) Targeting amino acid metabolism for cancer therapy. Drug Discov Today, 22 (5). pp. 796-804. ISSN 1878-5832

DOI: 10.1016/j.drudis.2016.12.003


To support sustained biomass accumulation, tumor cells undergo metabolic reprogramming. Nutrient transporters and metabolic enzymes are regulated by the same oncogenic signals that drive cell-cycle progression. Some of the earliest cancer therapies used antimetabolites to disrupt tumor metabolism, and there is now renewed interest in developing drugs that target metabolic dependencies. Many cancers exhibit increased demand for specific amino acids, and become dependent on either an exogenous supply or upregulated de novo synthesis. Strategies to exploit such 'metabolic addictions' include depleting amino acids in blood serum, blocking uptake by transporters and inhibiting biosynthetic or catabolic enzymes. Recent findings highlight the importance of using appropriate model systems and identifying target patient groups as potential therapies advance into the clinic.

Item Type: Paper
Subjects: diseases & disorders > cancer > drugs and therapies
organs, tissues, organelles, cell types and functions > organs types and functions > metabolism
diseases & disorders > cancer > drugs and therapies > tumor microenvironment
CSHL Authors:
Communities: CSHL labs > Lukey lab
Depositing User: Adrian Gomez
Date: May 2017
Date Deposited: 27 Jan 2020 18:22
Last Modified: 27 Jan 2020 18:22
PMCID: PMC5429979
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