A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis

Katt, W. P., Lukey, M. J., Cerione, R. A. (January 2017) A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis. Future Med Chem, 9 (2). pp. 223-243. ISSN 1756-8927

URL: https://www.ncbi.nlm.nih.gov/pubmed/28111979
DOI: 10.4155/fmc-2016-0190


Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption is upregulated relative to healthy cells. This metabolic reprogramming often depends upon mitochondrial glutaminase activity, which converts glutamine to glutamate, a key precursor for biosynthetic and bioenergetic processes. Two isozymes of glutaminase exist, a kidney-type (GLS) and a liver-type enzyme (GLS2 or LGA). While a majority of studies have focused on GLS, here we summarize key findings on both glutaminases, describing their structure and function, their roles in cancer and pharmacological approaches to inhibiting their activities.

Item Type: Paper
Additional Information: Corrigendum: https://www.future-science.com/doi/abs/10.4155/fmc-2016-0190c1?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=fmc
Subjects: diseases & disorders > neoplasms
bioinformatics > genomics and proteomics > alignment > sequence alignment
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
CSHL Authors:
Communities: CSHL labs > Lukey lab
Depositing User: Adrian Gomez
Date: January 2017
Date Deposited: 27 Jan 2020 15:03
Last Modified: 27 Jan 2020 15:03
PMCID: PMC5558546
Related URLs:
URI: https://repository.cshl.edu/id/eprint/38932

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