Katt, W. P., Lukey, M. J., Cerione, R. A. (January 2017) A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis. Future Med Chem, 9 (2). pp. 223-243. ISSN 1756-8927
Abstract
Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption is upregulated relative to healthy cells. This metabolic reprogramming often depends upon mitochondrial glutaminase activity, which converts glutamine to glutamate, a key precursor for biosynthetic and bioenergetic processes. Two isozymes of glutaminase exist, a kidney-type (GLS) and a liver-type enzyme (GLS2 or LGA). While a majority of studies have focused on GLS, here we summarize key findings on both glutaminases, describing their structure and function, their roles in cancer and pharmacological approaches to inhibiting their activities.
| Item Type: | Paper |
|---|---|
| Additional Information: | Corrigendum: https://www.future-science.com/doi/abs/10.4155/fmc-2016-0190c1?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=fmc |
| Subjects: | diseases & disorders > neoplasms bioinformatics > genomics and proteomics > alignment > sequence alignment bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes |
| CSHL Authors: | |
| Communities: | CSHL labs > Lukey lab |
| Depositing User: | Adrian Gomez |
| Date: | January 2017 |
| Date Deposited: | 27 Jan 2020 15:03 |
| Last Modified: | 27 Jan 2020 15:03 |
| PMCID: | PMC5558546 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/38932 |
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