Excitatory and Inhibitory Subnetworks Are Equally Selective during Decision-Making and Emerge Simultaneously during Learning

Najafi, F., Elsayed, G. F., Cao, R., Pnevmatikakis, E., Latham, P. E., Cunningham, J. P., Churchland, A. K. (October 2019) Excitatory and Inhibitory Subnetworks Are Equally Selective during Decision-Making and Emerge Simultaneously during Learning. Neuron, 105 (1). pp. 165-179. ISSN 0896-6273 (Public Dataset)

Abstract

Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connectivity in slice. The selectivity of excitatory and inhibitory neurons within decision circuits and, hence, the validity of decision-making models are unknown. We simultaneously measured excitatory and inhibitory neurons in the posterior parietal cortex of mice judging multisensory stimuli. Surprisingly, excitatory and inhibitory neurons were equally selective for the animal's choice, both at the single-cell and population level. Further, both cell types exhibited similar changes in selectivity and temporal dynamics during learning, paralleling behavioral improvements. These observations, combined with modeling, argue against circuit architectures assuming non-selective inhibitory neurons. Instead, they argue for selective subnetworks of inhibitory and excitatory neurons that are shaped by experience to support expert decision-making.

Item Type:	Paper
Subjects:	organism description > animal organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal behavior > decision making organism description > animal behavior > learning organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > parietal cortex organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Churchland, Anne K. Najafi, Farzaneh
Communities:	CSHL labs > Churchland lab
Depositing User:	Adrian Gomez
Date:	25 October 2019
Date Deposited:	11 Dec 2019 16:08
Last Modified:	02 Feb 2024 19:36
PMCID:	PMC6952547
Related URLs:	Publisher
Dataset ID:	http://repository.cshl.edu/36980/ Code:https://github.com/farznaj/imaging_decisionMaking_exc_inh http://repository.cshl.edu/id/eprint/37693
URI:	https://repository.cshl.edu/id/eprint/38739

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