Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts

Won, Kwang-Ai, Xiong, Yue, Beach, David, Gilman, Michael Z. (1972) Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. Proceedings of the National Academy of Sciences of the United States of America, 89 (20). pp. 9910-9914.

Abstract

The human CCND1 cyclin D1/PRAD1 gene was previously identified by a genetic screen for G-1 cyclin function in Saccharomyces cerevisiae and also was identified as the putative BCL1 oncogene. Treatment of HDFs with defined growth factors suggests a correlation between CCND mRNA induction and DNA synthesis. However, induction of these genes is not sufficient for the transition from quiescence through G-1 into S phase.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation
CSHL Authors:
Communities: Cold Spring Harbor Laboratory of Quantitative Biology
Depositing User: Elizabeth Pessala
Date: 1972
Date Deposited: 15 Apr 2019 17:01
Last Modified: 15 Apr 2019 17:01
URI: https://repository.cshl.edu/id/eprint/37340

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