Schorn, A. J., Martienssen, R. A. (October 2018) Tie-Break: Host and Retrotransposons Play tRNA. Trends in Cell Biology, 28 (10). pp. 793-806. ISSN 0962-8924
Abstract
tRNA fragments (tRFs) are a class of small, regulatory RNAs with diverse functions. 3′-Derived tRFs perfectly match long terminal repeat (LTR)-retroelements which use the 3′-end of tRNAs to prime reverse transcription. Recent work has shown that tRFs target LTR-retroviruses and -transposons for the RNA interference (RNAi) pathway and also inhibit mobility by blocking reverse transcription. The highly conserved tRNA primer binding site (PBS) in LTR-retroelements is a unique target for 3′-tRFs to recognize and block abundant but diverse LTR-retrotransposons that become transcriptionally active during epigenetic reprogramming in development and disease. 3′-tRFs are processed from full-length tRNAs under so far unknown conditions and potentially protect many cell types. tRFs appear to be an ancient link between RNAi, transposons, and genome stability.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > tRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transposons |
| CSHL Authors: | |
| Communities: | CSHL labs > Martienssen lab CSHL labs > Schorn lab |
| Depositing User: | Matt Covey |
| Date: | October 2018 |
| Date Deposited: | 20 Jun 2018 21:00 |
| Last Modified: | 15 Nov 2023 18:27 |
| PMCID: | PMC6520983 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/36752 |
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