An Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb

Banerjee, A., Marbach, F., Anselmi, F., Koh, M. S., Davis, M. B., Garcia da Silva, P., Delevich, K., Oyibo, H. K., Gupta, P., Li, B., Albeanu, D. F. (July 2015) An Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb. Neuron, 87 (1). pp. 193-207. ISSN 0896-6273

Abstract

Odors elicit distributed activation of glomeruli in the olfactory bulb (OB). Crosstalk between co-active glomeruli has been proposed to perform a variety of computations, facilitating efficient extraction of sensory information by the cortex. Dopaminergic/GABAergic cells in the OB, which can be identified by their expression of the dopamine transporter (DAT), provide the earliest opportunity for such crosstalk. Here we show in mice that DAT+ cells carry concentration-dependent odor signals and broadcast focal glomerular inputs throughout the OB to cause suppression of mitral/tufted (M/T) cell firing, an effect that is mediated by the external tufted (ET) cells coupled to DAT+ cells via chemical and electrical synapses. We find that DAT+ cells implement gain control and decorrelate odor representations in the M/T cell population. Our results further indicate that ET cells are gatekeepers of glomerular output and prime determinants of M/T responsiveness.

Item Type:	Paper
Uncontrolled Keywords:	Animals Dopamine Plasma Membrane Transport Proteins/metabolism Dopaminergic Neurons/metabolism/*physiology GABAergic Neurons/metabolism/physiology Mice Neurons/metabolism/physiology *Odorants Olfactory Bulb/cytology/*physiology Synaptic Transmission/*physiology
Subjects:	bioinformatics > genomics and proteomics > small molecules > GABAergic bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dopamine organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron organs, tissues, organelles, cell types and functions > tissues types and functions > glomerulus organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:	Banerjee, Arkarup Marbach, Fred Anselmi, Francesca Koh, Matthew Davis, Martin Garcia Da Silva, Pedro Delevich, Kristen Oyibo, Hassana K. Gupta, Priyanka Li, Bo Albeanu, Dinu F.
Communities:	CSHL labs > Albeanu lab CSHL labs > Li lab CSHL labs > Zador lab School of Biological Sciences > Publications
Depositing User:	Matt Covey
Date:	1 July 2015
Date Deposited:	29 Nov 2017 17:04
Last Modified:	03 Jan 2019 16:25
PMCID:	PMC4633092
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/35674

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