Phares, W. (December 1988) Transduction of Proto-Src Sequences in Tissue Culture by a Molecular Clone of Transformation-Defective Rous Sarcoma Virus with an Internal Src Deletion. Journal of Virology, 62 (12). pp. 4791-4796. ISSN 0022-538X
Abstract
The sporadic appearance of nondefective (nd) Rous sarcoma virus (RSV) from cells in tissue culture infected with a molecular clone of transformation-defective RSV was examined. Southern analysis of extrachromosomal, virus-specific DNA of three independent ndRSV isolates in each case indicated restoration of an isogenic src by homologous recombination with cellular proto-src. The frequency of transduction was estimated by fluctuation analysis to vary between one transduction per 0.4 .times. 107 to 1.6 .times. 107 infected cells.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer > cancer types > sarcoma bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction organism description > virus |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Gail Sherman |
| Date: | December 1988 |
| Date Deposited: | 26 Sep 2017 18:33 |
| Last Modified: | 26 Sep 2017 18:33 |
| PMCID: | PMC253601 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/35195 |
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