Franza, B. R., Rauscher, F. J., Josephs, S. F., Curran, T. (March 1988) The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science, 239 (4844). pp. 1150-3. ISSN 0036-8075
Abstract
The Fos protein complex and several Fos-related antigens bind directly or indirectly to a common sequence element that is similar to the consensus binding site for HeLa cell activator protein 1 (AP-1). This element is present in a negative regulatory sequence in the differentiation-sensitive adipocyte gene, aP2; in a transcriptional enhancer for the Gibbon ape leukemia virus; and in a region of the human immunodeficiency virus (HIV) long terminal repeat partially characterized as a negative regulatory element. The protein level and binding activity of Fos and Fos-related antigens increase rapidly after calcium ionophore treatment of a CD4+ human lymphoblast cell line, H9. These data suggest that several proteins may associate with the AP-1 binding site. Moreover, temporally regulated control of the level of each protein could represent a mechanism for modulation of these putative mediators of gene expression.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Base Sequence Binding Sites Calcimycin/pharmacology Cell Line Dna Electrophoresis, Polyacrylamide Gel Enhancer Elements (Genetics) HIV/genetics Humans Immunoassay Immunosorbent Techniques Molecular Sequence Data Precipitation Proto-Oncogene Proteins/analysis/genetics/immunology/*metabolism Proto-Oncogene Proteins c-fos Proto-Oncogenes Regulatory Sequences, Nucleic Acid Repetitive Sequences, Nucleic Acid Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. T-Lymphocytes, Helper-Inducer/cytology/drug effects |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types organism description > virus |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Gail Sherman |
| Date: | 4 March 1988 |
| Date Deposited: | 13 Oct 2017 17:12 |
| Last Modified: | 13 Oct 2017 17:12 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/35149 |
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