The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites

Franza, B. R., Rauscher, F. J., Josephs, S. F., Curran, T. (March 1988) The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science, 239 (4844). pp. 1150-3. ISSN 0036-8075

URL: http://www.ncbi.nlm.nih.gov/pubmed/2964084
DOI: 10.1126/science.2964084

Abstract

The Fos protein complex and several Fos-related antigens bind directly or indirectly to a common sequence element that is similar to the consensus binding site for HeLa cell activator protein 1 (AP-1). This element is present in a negative regulatory sequence in the differentiation-sensitive adipocyte gene, aP2; in a transcriptional enhancer for the Gibbon ape leukemia virus; and in a region of the human immunodeficiency virus (HIV) long terminal repeat partially characterized as a negative regulatory element. The protein level and binding activity of Fos and Fos-related antigens increase rapidly after calcium ionophore treatment of a CD4+ human lymphoblast cell line, H9. These data suggest that several proteins may associate with the AP-1 binding site. Moreover, temporally regulated control of the level of each protein could represent a mechanism for modulation of these putative mediators of gene expression.

Item Type: Paper
Uncontrolled Keywords: Base Sequence Binding Sites Calcimycin/pharmacology Cell Line Dna Electrophoresis, Polyacrylamide Gel Enhancer Elements (Genetics) HIV/genetics Humans Immunoassay Immunosorbent Techniques Molecular Sequence Data Precipitation Proto-Oncogene Proteins/analysis/genetics/immunology/*metabolism Proto-Oncogene Proteins c-fos Proto-Oncogenes Regulatory Sequences, Nucleic Acid Repetitive Sequences, Nucleic Acid Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. T-Lymphocytes, Helper-Inducer/cytology/drug effects
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organism description > virus
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: 4 March 1988
Date Deposited: 13 Oct 2017 17:12
Last Modified: 13 Oct 2017 17:12
Related URLs:
URI: https://repository.cshl.edu/id/eprint/35149

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