Forget before you remember: dynamic mechanism of memory decay and retrieval

Engel, T., Andrieux, D. (2010) Forget before you remember: dynamic mechanism of memory decay and retrieval. Front Neurosci, 4 (3). p. 3. ISSN 1662-453X (Electronic)1662-453X (Linking)

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DOI: 10.3389/neuro.01.003.2010


Sensory systems are confronted with a continuous stream of inputs, but only a small fraction of these sensory stimuli reaches our awareness, is consciously perceived and can be remembered. Perception is never driven solely by the bottom-up stimulation, but crucially depends on the top-down modulations. Top-down signals convey behavioral context, such as attention, expectation and perceptual task, and are reflected in the context-specific response modulation in single neurons (Miller and Cohen, 2001 ; Corbetta and Shulman, 2002 ). Top-down interactions can be of many different kinds: augmenting or multiplying responses, sharpening tuning curves, controlling contextual influences, or acting as a modulator of plasticity (Desimone and Duncan, 1995 ; Maunsell and Treue, 2006 ). Although a lot of empirical knowledge has been accumulated on how top-down interactions modulate neural responses, only a few theoretical attempts have been made so far to explain the underlying biophysical mechanisms and to bridge the gap between the behavioral and single-cell data (Buia and Tiesinga, 2006 ; Deco and Rolls, 2006 ; Ardid et al., 2007 ).

Item Type: Paper
Subjects: organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Engel lab
Depositing User: Matt Covey
Date: 2010
Date Deposited: 14 Aug 2017 20:38
Last Modified: 06 Nov 2017 20:52
PMCID: PMC2891836
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