Hanahan, D., Jolicoeur, C., Alpert, S., Skowronski, J. (June 1989) Alternative Self or Nonself Recognition of an Antigen Expressed in a Rare Cell Type in Transgenic Mice - Implications for Self-Tolerance and Autoimmunity. Cold Spring Harbor Symposia on Quantitative Biology, 54. pp. 821-835. ISSN 0091-7451
Abstract
During its development, the immune system acquires the ability to recognize and respond to a wide variety of cells and other entities from the outside environment (Hood et al. 1984; Roitt et al. 1985). A necessary feature of this capacity is the ability to discriminate between what is a normal component of the body (self) and what is not (foreign or nonself). The existence of immunological tolerance toward self has been wellestablished for many years, and mechanisms that could serve to achieve it have been postulated and increasingly refined as our knowledge of the development, organization, and function of the immune system has progressed (Burnet 1959; Dresser and Mitchison 1968; Bretscher and Cohn 1970; Weigle 1973; Howard and Mitchison 1975; Nossal 1983; Schwartz 1989). The importance of self-tolerance can be seen in the damages wrought by autoimmune diseases, such as insulindependent diabetes, in which the immune system becomes self-reactive against specific cells and seeks to destroy them. In the case of diabetes, the autoimmune response succeeds in destroying the pancreatic/3 cells, resulting in a condition of insulin insufficiency and consequent deleterious effects throughout the body (Rossini et ai. 1985). Regarding the principles of self, the possibility is evident that failures to establish or maintain a condition of nonresponsiveness toward selfantigens could be a factor in the induction of autoimmune responses. Thus, one may in principle be able to relate the conditions of tolerance and autoimmunity through the mechanisms of seif/nonself recognition.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | MAJOR HISTOCOMPATIBILITY COMPLEX PANCREATIC BETA-CELLS SV40 T-ANTIGEN MONOCLONAL-ANTIBODY LYMPHOCYTES-T TRANSPLANTATION ANTIGEN IMMUNOLOGICAL-TOLERANCE 5'-FLANKING REGION ENDOCRINE-CELLS HYBRID INSULIN |
| Subjects: | bioinformatics > genomics and proteomics organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal |
| CSHL Authors: | |
| Communities: | CSHL labs > Skowronski lab |
| Depositing User: | Gail Sherman |
| Date: | June 1989 |
| Date Deposited: | 27 Jul 2017 18:47 |
| Last Modified: | 27 Jul 2017 18:47 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34857 |
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