Hershey, Alfred Day, Burgi, Elizabeth (1956) Genetic significance of the transfer of nucleic acid from parental to offspring phage. Cold Spring Harbor Symposia on Quantitative Biology, 21. pp. 91-101.
Abstract
Putnam and Kozloff (1950) first demonstrated that labeled atoms derived from a parental generation of phage particles were partly conserved among the viral offspring. Subsequent work showed that the conserved atoms were derived from and transferred to deoxyribonucleic acid (DNA), chiefly or exclusively (Hershey and Chase, 1952; Kozloff, 1953; French, 1954). What can this phenomenon tell us about genetic replication and recombination? The selective transfer of DNA is not itself very informative: most of the viral protein fails to enter the cell at the time of infection and is unavailable for transfer (Hershey and Chase, 1952). Moreover, the same selectivity is observed when one examines the utilization of labeled bacterial constituents for viral growth: only the DNA is utilized efficiently (Kozloff et al., 1951; Hershey et al., 1954).
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene transfer |
| CSHL Authors: | |
| Communities: | The Carnegie Institution Department of Genetics |
| Depositing User: | Matt Covey |
| Date: | 1956 |
| Date Deposited: | 19 Apr 2017 19:03 |
| Last Modified: | 19 Apr 2017 19:03 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34516 |
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