Krishnan, K., Lau, B. Y., Ewall, G., Huang, Z. J., Shea, S. D. (January 2017) MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice. Nat Commun, 8. p. 14077. ISSN 2041-1723 (Electronic)2041-1723 (Linking)
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Abstract
Neurodevelopmental disorders are marked by inappropriate synaptic connectivity early in life, but how disruption of experience-dependent plasticity contributes to cognitive and behavioural decline in adulthood is unclear. Here we show that pup gathering behaviour and associated auditory cortical plasticity are impaired in female Mecp2het mice, a model of Rett syndrome. In response to learned maternal experience, Mecp2het females exhibited transient changes to cortical inhibitory networks typically associated with limited plasticity. Averting these changes in Mecp2het through genetic or pharmacological manipulations targeting the GABAergic network restored gathering behaviour. We propose that pup gathering learning triggers a transient epoch of inhibitory plasticity in auditory cortex that is dysregulated in Mecp2het. In this window of heightened sensitivity to sensory and social cues, Mecp2 mutations suppress adult plasticity independently from their effects on early development.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > MECP2 bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > methyl-CpG-binding protein 2 organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity |
| CSHL Authors: | |
| Communities: | CSHL labs > Huang lab CSHL labs > Shea lab |
| Depositing User: | Matt Covey |
| Date: | 18 January 2017 |
| Date Deposited: | 26 Jan 2017 17:18 |
| Last Modified: | 24 May 2021 17:10 |
| PMCID: | PMC5253927 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34052 |
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