Mutation-biased adaptation in Andean house wrens

Stoltzfus, A., McCandlish, D. M. (November 2015) Mutation-biased adaptation in Andean house wrens. Proc Natl Acad Sci U S A, 112 (45). pp. 13753-4. ISSN 1091-6490 (Electronic)0027-8424 (Linking)

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DOI: 10.1073/pnas.1518490112


Genes, proteins, and genomes are pervasively shaped by biases in mutation that exert their influence by biasing rates of evolutionary change. Indeed, methods of phylogeny inference routinely assume that evolutionary rates will reflect transition–transversion bias and other common mutational biases. This influence is typically attributed to neutral evolution, presuming that mutation is a weak force easily overcome by selection, so that any noticeable effect of mutation must signal a lack of selection. However, in PNAS Galen et al. (1) propose a case of mutation-biased adaptation, in which the course of evolution reflects both a bias in mutation and a fitness benefit. How important are mutational biases in shaping adaptation? Are internal sources of orientation or direction in evolution—once dismissed as improbable (2)—more important than previously imagined?

Item Type: Paper
Uncontrolled Keywords: Adaptation, Biological/*genetics *Altitude Animals Hemoglobins/*metabolism *Phenotype Point Mutation/*genetics Songbirds/*genetics beta-Globins/*genetics
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
bioinformatics > genomics and proteomics > annotation > phenotyping
CSHL Authors:
Communities: CSHL labs > McCandlish lab
Depositing User: Matt Covey
Date: 10 November 2015
Date Deposited: 18 Jan 2017 21:01
Last Modified: 08 Nov 2017 20:08
PMCID: PMC4653193
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