Stoltzfus, A., McCandlish, D. M. (November 2015) Mutation-biased adaptation in Andean house wrens. Proc Natl Acad Sci U S A, 112 (45). pp. 13753-4. ISSN 1091-6490 (Electronic)0027-8424 (Linking)
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Abstract
Genes, proteins, and genomes are pervasively shaped by biases in mutation that exert their influence by biasing rates of evolutionary change. Indeed, methods of phylogeny inference routinely assume that evolutionary rates will reflect transition–transversion bias and other common mutational biases. This influence is typically attributed to neutral evolution, presuming that mutation is a weak force easily overcome by selection, so that any noticeable effect of mutation must signal a lack of selection. However, in PNAS Galen et al. (1) propose a case of mutation-biased adaptation, in which the course of evolution reflects both a bias in mutation and a fitness benefit. How important are mutational biases in shaping adaptation? Are internal sources of orientation or direction in evolution—once dismissed as improbable (2)—more important than previously imagined?
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adaptation, Biological/*genetics *Altitude Animals Hemoglobins/*metabolism *Phenotype Point Mutation/*genetics Songbirds/*genetics beta-Globins/*genetics |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations bioinformatics > genomics and proteomics > annotation > phenotyping |
| CSHL Authors: | |
| Communities: | CSHL labs > McCandlish lab |
| Depositing User: | Matt Covey |
| Date: | 10 November 2015 |
| Date Deposited: | 18 Jan 2017 21:01 |
| Last Modified: | 08 Nov 2017 20:08 |
| PMCID: | PMC4653193 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34035 |
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