Patel, T. V., Morgan, J. A., Demetri, G. D., George, S., Maki, R. G., Quigley, M., Humphreys, B. D. (February 2008) A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib. J Natl Cancer Inst, 100 (4). pp. 282-4. ISSN 1460-2105 (Electronic)0027-8874 (Linking)
Abstract
The oral multitargeted kinase inhibitors (MTKI) sunitinib (SU11248, Sutent; Pfizer, New York) and sorafenib (BAY 43-9006, Nexavar; Bayer Pharmaceuticals, West Haven, CT, and Onyx Pharmaceuticals, Emeryville, CA) are increasingly used to treat malignant solid tumors. These small-molecule agents inhibit signaling through receptor tyrosine kinases such as vascular endothelial growth factor (VEGF) receptor, platelet-derived growth factor receptor, and c-KIT, among others (1). In the kidney, glomerular podocytes express VEGF and glomerular endothelial cells express VEGF receptors. Podocyte-specific deletion of a single VEGF allele causes proteinuria and capillary endotheliosis in rodents, and disrupted glomerular VEGF signaling is strongly implicated in the pathogenesis of human preeclampsia (2–4).
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Antineoplastic Agents/*adverse effects Benzenesulfonates/*adverse effects Humans Hypertension/*chemically induced/metabolism Indoles/*adverse effects Niacinamide/analogs & derivatives Phenylurea Compounds Protein Kinase Inhibitors/*adverse effects Proteinuria/*chemically induced/metabolism Pyridines/*adverse effects Pyrroles/*adverse effects Receptors, Vascular Endothelial Growth Factor/*drug effects Signal Transduction/drug effects |
| Subjects: | diseases & disorders > cancer diseases & disorders > cancer > drugs and therapies |
| CSHL Authors: | |
| Communities: | CSHL labs > Maki lab |
| Depositing User: | Matt Covey |
| Date: | 20 February 2008 |
| Date Deposited: | 26 Oct 2016 14:47 |
| Last Modified: | 26 Oct 2016 14:47 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/33691 |
Actions (login required)
 |
Administrator's edit/view item |