Maki, R. G., Livingston, P. O., Lewis, J. J., Janetzki, S., Klimstra, D., Desantis, D., Srivastava, P. K., Brennan, M. F. (August 2007) A phase I pilot study of autologous heat shock protein vaccine HSPPC-96 in patients with resected pancreatic adenocarcinoma. Dig Dis Sci, 52 (8). pp. 1964-72. ISSN 0163-2116 (Print)0163-2116 (Linking)
Abstract
We performed a phase I pilot study to determine if autologous vaccine HSPPC-96 (gp96, Oncophage) could be purified from completely resected pancreas adenocarcinomas, to determine patient tolerance of vaccine and to explore immune responses and clinical outcomes of these patients. Subjects were vaccinated with 5 microg of autologous HSPPC-96 weekly for 4 doses. Serial ELISPOT assays of T cells for antitumor reactivity were performed. Subjects received neither adjuvant chemotherapy nor radiation. Ten patients received a full course of vaccinations. No dose-limiting toxicities were encountered. Immediate freezing in liquid nitrogen of the tumor specimen resulted in improved vaccine yield. Median overall survival is 2.2 years (Kaplan-Meier estimate). Autologous anti-HSPPC-96 ELISPOT reactivity increased significantly in 1 of 5 patients examined and a second had an increase of unclear significance. Three of 10 treated patients are alive without disease at 2.6, 2.7, and 5.0 years follow-up. There was no observed correlation between immune response and prognosis. This study demonstrates the feasibility of preparing HSPPC-96 from pancreatic adenocarcinomas. Examination of this novel approach using multiple dose levels is 1 approach to further investigate the immunogenicity and clinical utility of HSPPC-96 vaccination in this setting.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adenocarcinoma/mortality/surgery/*therapy Aged Cancer Vaccines/*therapeutic use/toxicity Female Heat-Shock Proteins/*therapeutic use/toxicity Humans Immune Tolerance Immunization Schedule Male Middle Aged Pancreatic Neoplasms/surgery/*therapy Pilot Projects T-Lymphocytes/immunology Treatment Outcome |
| Subjects: | diseases & disorders > cancer > cancer types > pancreatic cancer |
| CSHL Authors: | |
| Communities: | CSHL labs > Maki lab |
| Depositing User: | Matt Covey |
| Date: | August 2007 |
| Date Deposited: | 26 Oct 2016 19:23 |
| Last Modified: | 26 Oct 2016 19:23 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/33675 |
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