Eilber, F. C., Brennan, M. F., Eilber, F. R., Eckardt, J. J., Grobmyer, S. R., Riedel, E., Forscher, C., Maki, R. G., Singer, S. (July 2007) Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Ann Surg, 246 (1). pp. 105-13. ISSN 0003-4932 (Print)0003-4932 (Linking)
Abstract
PURPOSE: To determine if ifosfamide-based chemotherapy (IF) offers a survival benefit to adult patients with primary extremity synovial sarcoma. PATIENTS AND METHODS: Prospectively collected patient data from 2 institutions was used to identify all adult patients (>or=16 years) with >or=5 cm, deep, primary, extremity, synovial sarcoma that underwent surgical treatment of cure from 1990 to 2002. A total of 101 patients were identified and the median follow-up for survivors was 58 months. Clinical, pathologic, and treatment variables were analyzed for disease-specific survival (DSS), distant recurrence-free survival (DRFS), and local recurrence-free survival (LRFS). RESULTS: Sixty-eight (67%) patients were treated with IF and 33 (33%) patients received no chemotherapy (NoC) for the primary tumor. The characteristics of the IF-treated patients [median tumor size = 7.2 cm; monophasic n = 46 (68%)] were similar to NoC patients [median tumor size = 7 cm; monophasic n = 23 (70%)]. The 4-year DSS of the IF-treated patients was 88% compared with 67% for the NoC patients (P = 0.01). Smaller size (HR = 0.3 per 5-cm decrease, P < 0.0001) and treatment with IF (HR = 0.3 compared with NoC, P = 0.007) were independently associated with an improved DSS. Treatment with IF was independently associated with an improved DRFS (HR = 0.4, P = 0.03) but not associated with an improved LRFS (P = 0.39). CONCLUSION: Ifosfamide-based chemotherapy was associated with an improved DSS in adult patients with high-risk, primary, extremity, synovial sarcoma and should be considered in the treatment of such patients.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adolescent Adult Aged Antibiotics, Antineoplastic/therapeutic use Antineoplastic Agents, Alkylating/therapeutic use *Arm Disease-Free Survival Doxorubicin/*therapeutic use Female Follow-Up Studies Humans Ifosfamide/*therapeutic use *Leg Male Middle Aged Neoplasm Recurrence, Local/mortality Prospective Studies Sarcoma, Synovial/*drug therapy/*mortality Survival Rate/trends Treatment Outcome |
| Subjects: | diseases & disorders > cancer > drugs and therapies > chemotherapy diseases & disorders > cancer > drugs and therapies diseases & disorders > cancer > cancer types > sarcoma |
| CSHL Authors: | |
| Communities: | CSHL labs > Maki lab |
| Depositing User: | Matt Covey |
| Date: | July 2007 |
| Date Deposited: | 26 Oct 2016 19:11 |
| Last Modified: | 26 Oct 2016 19:11 |
| PMCID: | PMC1899195 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/33671 |
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