Mathews, M. B. (August 1993) Viral Evasion of Cellular Defense-Mechanisms - Regulation of the Protein-Kinase Dai by Rna Effectors. Seminars in Virology, 4 (4). pp. 247-257. ISSN 1044-5773
Abstract
The protein kinase DAI (the double-stranded RNA activated inhibitor) plays a critical role in controlling translation in uninfected and infected cells. It is induced by interferon as part of the cellular antiviral defense mechanism. When activated, it leads to a blockade of polypeptide chain initiation, thereby interrupting viral propagation. Many viruses have developed means to neutralize the action of DAI: the sheer profusion of these countermeasures makes it clear that DAI is an important component of the host antiviral defense mechanism and a serious concern to the viruses. This chapter focusses on the mechanism of DAI activation and its inhibition by virus-encoded RNA antidotes.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | PROTEIN KINASE DAI EIF-2 DOUBLE-STRANDED RNA VIRAL RNA INTERFERON ANTIVIRAL DEFENSE MECHANISMS DOUBLE-STRANDED-RNA EPSTEIN-BARR-VIRUS INITIATION FACTOR-II ADENOVIRUS VA RNAI TAT GENE-PRODUCT MESSENGER-RNA INTERFERON ACTION INFECTED-CELLS TRANSLATIONAL CONTROL STRUCTURAL REQUIREMENTS |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > dsRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | August 1993 |
| Date Deposited: | 08 Apr 2016 15:14 |
| Last Modified: | 08 Apr 2016 15:14 |
| URI: | https://repository.cshl.edu/id/eprint/32601 |
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